Aquaporin-1 Expression in Herniated Human Lumbar Intervertebral Discs

Aquaporin-1 Expression in Herniated Human Lumbar Intervertebral Discs

STUDY DESIGN Case series. OBJECTIVE Intervertebral disc (IVD) degeneration is the cause of spondylosis. The pathogenesis is poorly understood, but disc dehydration often plays a role. In this study, we aim to identify and quantify aquaporin-1 (AQP1) in ex vivo human degenerated IVDs obtained intraoperatively and to investigate the relationship between AQP1 levels and magnetic resonance imagin...

DR5 and DcR2 Expression in Human Lumbar Intervertebral Discs

IVD degeneration occurs frequently in adult humans and is associated with low back pain and disc herniation. Despite enormous clinical and research efforts, the mechanism of IVD degeneration is still not fully understood. Evidence has indicated that programmed cell death (PCD) plays an important role in some human degenerative diseases. Three members of the TNF-a ligand superfamily, Fas ligand,...

Measuring Dimensions of Lumbar Intervertebral Discs in Normal Subjects

Introduction: Disc degeneration is a natural aging process characterized by changes in appearance and chemical structure of the disc. This degeneration leads to back pain. In regard to the limitation of current therapeutical methods for patients with degenerated discs, arthroplasty has been suggested as an alternative method. To manufacture artificial discs for Iranians, determining normal lumb...

Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile

Low back pain is a common and debilitating disorder. Current evidence implicates intervertebral disc (IVD) degeneration and herniation as major causes, although the pathogenesis is poorly understood. While several cytokines have been implicated in the process of IVD degeneration and herniation, investigations have predominately focused on Interleukin 1 (IL-1) and tumor necrosis factor alpha (TN...

Herniated intervertebral lumbar disc in the teenager.